reduction in non syndromic oral clefts following mandatory flour fortification with folic acid in northern iran
نویسندگان
چکیده
background: several studies have examined the effects of folic acid fortification on the occurrence of orofacial clefts. this study was carried out to evaluate the impact of flour fortification with folic acid on oral clefts in northern iran. methods : in this hospital based study from march 2006 to september 2009, we screened the total number of live births at all hospitals in golestan province in north of iran, as well as the number of pregnancies affected by non syndromic oral clefts, per 100000 births during the periods before (march 2006 –june 2007), during (july2007-march 2008) and after (may 2008- september 2009) folic acid fortification of flour was implemented. non syndromic oral clefts were defined in accordance with the international classification of diseases, 10th revision (icd-10). results: the prevalence of oral clefting reduced from 64.2 per 100000 births before fortification to 32.2 per 100000 after flour fortification with folic acid. the preventive fraction rate of oral clefting after fortification period in comparison with before period was 49.8% (or=0.502 95% ci 0.26-0.97, p=0.036). conclusion: this study showed that flour fortification with folic acid is associated with a significant reduction in the rate of oral clefting in golestan province in northern iran.
منابع مشابه
Reduction in non syndromic oral clefts following mandatory flour fortification with folic acid in Northern Iran
Background: Several studies have examined the effects of folic acid fortification on the occurrence of orofacial clefts. This study was carried out to evaluate the impact of flour fortification with folic acid on oral clefts in Northern Iran. Methods : In this hospital based study from March 2006 to September 2009, we screened the total number of live births at all hospitals in Golestan pro...
متن کاملReduction in non syndromic oral clefts following mandatory flour fortification with folic acid in Northern Iran
UNLABELLED Background Several studies have examined the effects of folic acid fortification on the occurrence of orofacial clefts. This study was carried out to evaluate the impact of flour fortification with folic acid on oral clefts in Northern Iran. METHODS In this hospital based study from March 2006 to September 2009, we screened the total number of live births at all hospitals in Golest...
متن کاملEfficacy of flour fortification with folic acid in women of childbearing age in Iran.
BACKGROUND Flour fortification with folic acid is one of the main strategies for improving folate status in women of childbearing age. No interventional trial on the efficacy of folic acid fortification has been conducted so far in Iran. OBJECTIVES To study the effects of flour fortification with folic acid on any reduction in neural tube defects (NTDs) and folate status of women of childbear...
متن کاملIncreasing evidence in favour of mandatory fortification with folic acid.
Folic acid fortification of grain foods on a mandatory basis has been in place in the USA since 1998. Because of the safety concerns surrounding this issue, the Food and Drug Administration in the USA, responsible for implementing the new fortification legislation, opted for the relatively low folic acid concentration of 1400mg/kg product, (United States Department of Health and Human Services,...
متن کاملIncreasing evidence in favour of mandatory fortification with folic acid
Folic acid fortification of grain foods on a mandatory basis has been in place in the USA since 1998. Because of the safety concerns surrounding this issue, the Food and Drug Administration in the USA, responsible for implementing the new fortification legislation, opted for the relatively low folic acid concentration of 1400mg/kg product, (United States Department of Health and Human Services,...
متن کاملThe cost-effectiveness of mandatory folic acid fortification in Australia.
The Australian government recently introduced mandatory folic acid fortification of bread to reduce the incidence of neural tube defects (NTDs). The economic evaluation of this policy contained a number of limitations. This study aimed to address the limitations and to reconsider the findings. Cost-effectiveness analysis was used to assess the cost and benefits of mandatory versus voluntary fol...
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عنوان ژورنال:
medical journal of islamic republic of iranجلد ۲۸، شماره ۱، صفحات ۱۸۳-۱۸۷
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